Celecoxib Combined with Thalidomide in the Treatment

Celecoxib Combined with Thalidomide in the Treatment of Refractory Neoplastic Fever in Advanced Cholangiocarcinoma: A Case Report

A B S T R A C T

Neoplastic fever, a common symptom of tumors, can be mainly controlled by nonsteroidal anti-inflammatories (NSAIDs) and corticosteroids. However, there is no standard treatment guideline for refractory neoplastic fever, which cannot be controlled by the medicines mentioned above. This report presents a case of advanced cholangiocarcinoma with persistent fever lasting 3 weeks. After ineffective treatment with various antibiotics, ibuprofen, and corticosteroids, the body temperature returned to normal after a 48-hour treatment with celecoxib + thalidomide. Finally, the overall survival (OS) of the patient reached 8 months with radiotherapy and chemotherapy.

Keywords

Celecoxib, thalidomide, neoplastic fever, cholangiocarcinoma


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Article Type
Case Report

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© 2023 Kaijian Lei. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.

DOI: 10.31487/j.JSO.2020.06.06


Author Info

Qiu-yuan Liang

Kaijian Lei

Shan-Bing Wang

Yue Ren

Yan Xu


Corresponding Author
Kaijian Lei
Department of Oncology, The Second People’s Hospital of Yibin, Yibin, Sichuan, China

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